Synthetic BiologyNature CommunicationsPeer-reviewed
Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols
Björn D. M. Bean, Colleen J. Mulvihill, Riddhiman K. Garge…·Vincent J. J. Martin
This study engineers yeast to produce cholesterol, enabling functional expression of human opioid and other GPCRs, creating biosensors with measurable agonist responses and antagonist inhibition.
26 citations