Cancer BiologyeLifePeer-reviewed
Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning
Gabriella O. Estevam, Edmond M. Linossi, Jingyou Rao…·James S. Fraser
The paper uses deep mutational scanning to analyze MET kinase domain mutations and their resistance to 11 inhibitors, identifying resistance and sensitizing mutations and improving prediction with a protein language model.
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