Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization
William John Young, Najim Lahrouchi, Aaron J. Isaacs…·Antônio Luiz Pinho Ribeiro
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Erasmus MCORCID 0000-0002-4929-026XUnclaimed ORCID profile · follow to get notified of new preprints
5 papers
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William John Young, Najim Lahrouchi, Aaron J. Isaacs…·Antônio Luiz Pinho Ribeiro
Ιωάννα Ντάλλα, Lu-Chen C Weng, James Cartwright…·Dan M. Roden
This study identifies 210 genetic loci associated with the PR interval through multi-ancestry GWAS, highlighting their role in cardiac conduction and cardiovascular disease.
Alexander Teumer, Teresa Trenkwalder, Thorsten Kessler…·Wibke Reinhard
This study identifies a genome-wide significant association between a variant in the KCND3 gene and early repolarization pattern on ECG, suggesting a genetic basis for this trait.
Jianan Zhana, CHARGE ECG Working Group, Jessica van Setten…·Steven Ron Cummings
This paper introduces SAPPHO methods to detect pleiotropy in GWAS by modeling shared patterns of genetic associations, finding 16 additional and 124 novel loci in meta-analysis.
Jessica van Setten, Jennifer A. Brody, Yalda Jamshidi…·Paolo Gasparini
This study identifies 47 novel genetic loci associated with PR interval through genome-wide association meta-analysis across multiple populations.