Genetic & Genomic MedicinemedRxivPreprint
Elucidating mechanisms of genetic cross-disease associations: an integrative approach implicates protein C as a causal pathway in arterial and venous diseases
David Stacey, Lingyan Chen, Joanna M. M. Howson…·Dirk S. Paul
The paper identifies a genetic variant in PROCR that influences protein C and factor VII levels, linking it to both reduced coronary artery disease risk and increased venous thromboembolism risk through opposing inflammatory and thrombotic mechanisms.
4 citations