Molecular BiologyGenome biologyPeer-reviewed
Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying essential circRNAs
Yang Zhang, Tuan M. Nguyen, Xiao-Ou Zhang…·Pier Paolo Pandolfi
This study compares shRNA and CRISPR/Cas13d screens for circRNA function, finding that optimized CRISPR/Cas13d reduces false positives and identifies true functional circRNAs.
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