GenomicsNature BiotechnologyPeer-reviewed
Low copy CRISPR-Cas13d mitigates collateral RNA cleavage
Sydney K. Hart, Simon Müller, Hans‐Hermann Wessels…·Neville E. Sanjana
The paper evaluates collateral RNA cleavage in CRISPR-Cas13d systems and finds that low-copy expression reduces off-target effects while maintaining on-target knockdown.
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