Author
Broad InstituteORCID 0000-0002-5218-1689Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Corriene E. Sept, Y. Esther Tak, Christian G. Cerda-Smith…·Martin J. Aryee
The paper uses high-resolution CTCF MNase HiChIP data to analyze chromatin loop structures and introduces FactorFinder, finding that fully extruded CTCF-CTCF loops are rare and that chromatin state affects cohesin extrusion dynamics.
Christian G. Cerda-Smith, Haley M. Hutchinson, Annie Liu…·Kris C. Wood
The paper identifies 10 PTEN enhancers and proposes a new model of enhancer organization that includes spatial separation of functional and structural elements.
Allison P. Siegenfeld, Shelby A Roseman, Heejin Roh…·Brian B. Liau
The paper develops LIMe-Hi-C to study how Polycomb repressive complex 2 and lamina association regulate heterochromatin sub-compartments.
Suhas S.P. Rao, Su-Chen Eileen Huang, Brian Glenn St Hilaire…·Erez Lieberman Aiden
This study shows that cohesin loss eliminates loop domains, causing superenhancer links and gene downregulation, which are reversible upon cohesin restoration.