BiochemistrybioRxivPreprint
Inhibiting disulphide bonding in truncated tau297-391 results in enhanced self-assembly of tau into seed-competent assemblies.
Sebastian Scott Oakley, Karen E. Marshall, Georg Meisl…·Louise C. Serpell
This study investigates how inhibiting disulphide bonding in truncated tau affects its self-assembly into seed-competent structures, revealing enhanced aggregation rates and implications for tauopathy research.
DOI 10.1101/2025.02.05.636249