Heather Mead

Proteome-wide discovery of novel diagnostic antigens for coccidioidomycosis

This study identifies novel diagnostic antigens for coccidioidomycosis using high-dimensional peptide serology, showing improved accuracy in distinguishing infected individuals from controls.

A Novel Sarocladium spinificis Strain Suppresses Coccidioides posadasii Growth: Morphological and Genetic Perspectives

This study characterizes two clinical Sarocladium spinificis strains that inhibit Coccidioides posadasii growth, revealing their genomic features and potential antifungal properties.

Integrated, high-dimensional analysis of CD4 T cell epitope specificities and phenotypes reveals unexpected diversity in the response to Mycobacterium tuberculosis

The paper introduces CRESTA, a method to analyze CD4 T cell epitope specificities and phenotypes, revealing diverse responses to Mycobacterium tuberculosis.

Inferring the composition of a mixed culture of natural microbial isolates by deep sequencing

The paper develops a method to infer strain composition in microbial mixed cultures using natural SNPs as barcodes, validated on Coccidioides posadasii isolates and applied to GWAS.

Using double cut in vitro assembled CRISPR/Cas9 to modify the genome of Coccidioides posadasii

The paper identifies a defensin-like gene in Coccidioides posadasii with high transcript levels in spherules and uses CRISPR-Cas9 to delete it.

A chromosomal-level reference genome of the widely utilized Coccidioides posadasii laboratory strain "Silveira"

The paper presents a chromosomal-level genome assembly of the Coccidioides posadasii Silveira strain using SMRT sequencing, improving genome annotation and enabling future genomic studies.