Rachel B. Brem

This study uses single-cell RNA-seq and genetic approaches to identify a role for pyropoptosis-like cell death in enteroarthroconidial development in Coccidioides.

This study investigates the evolutionary transition of fungi from land to sea using Kluyveromyces yeasts, finding genome size reduction, phenotypic changes, and positive selection in marine species.

The paper analyzes genetic structure and diversity of Coccidioides immitis in environmental and human isolates to understand disease transmission and environmental distribution.

This study identifies genomic signatures of selection in Mus spicilegus, revealing accelerated evolution in brain-active genes linked to seasonal development and mound-building behavior.

This study identifies genetic mechanisms controlling temperature-dependent germination in the fungal thermophile Thermothelomyces thermophilus through insertional mutagenesis and validation of zinc transporter role.

This study identifies molecular and genetic features underlying stress resistance in the extremotolerant yeast Kluyveromyces marxianus through omic profiling and evolutionary analysis.

The paper compares lysosomal characteristics between fibroblasts of two mouse species, finding elevated lysosomal mass and enzyme activity in M. spretus compared to M. musculus.

The paper investigates how mitochondrial DNA variation and positive epistasis contribute to thermotolerance differences between Saccharomyces species.

This study shows Aedes sierrensis has heritable genetic variation in heat tolerance that could allow it to adapt to warming faster than projected climate changes.

This study identifies genetic adaptations in Myotis bats linked to longevity and viral tolerance through genome analysis and functional experiments.

The paper develops a method to infer strain composition in microbial mixed cultures using natural SNPs as barcodes, validated on Coccidioides posadasii isolates and applied to GWAS.

The paper identifies cutl-24 as a gene responsible for ER stress resistance in a Kenyan C. elegans isolate, showing parent-of-origin effects and validating its role through genetic experiments.

The paper presents a chromosomal-level genome assembly of the Coccidioides posadasii Silveira strain using SMRT sequencing, improving genome annotation and enabling future genomic studies.

This study identifies Musashi as a regulator of intestinal stem cell function in Drosophila, showing its role in improving survival and gut permeability after radiation exposure.

The paper identifies genetic mechanisms underlying diet-dependent lifespan and healthspan in D. melanogaster using GWAS and validates gene effects on lifespan and climbing ability.

This study identifies distinct TRP channel-dependent pathways through which S1PR3 mediates itch and pain in mice.

This study identifies eight housekeeping genes responsible for Saccharomyces cerevisiae's thermotolerance advantage over S. paradoxus using a new mapping approach in a sterile hybrid.

This study identifies sphingosine 1-phosphate and its receptor S1PR3 as critical regulators of mechanical pain by modulating mechanonociceptor excitability.

The paper develops a high-throughput genetics method for Rhodosporidium toruloides, identifies essential genes, and reveals key processes in lipid metabolism.