Mark Voorhies

This study identifies temperature-driven isoform switching in Histoplasma that reprograms developmental gene expression during thermal dimorphism.

This study optimizes conidial production in Histoplasma, identifying media and conditions that enhance conidiation and germination, and reveals strain-specific responses and cell wall composition differences.

This study shows that macrophage phagocytosis of Coccidioides arthroconidia promotes their differentiation into spherules, a pathogenic form, through direct interaction rather than soluble factors.

This study presents the first telomere-to-telomere genome assemblies for Histoplasma ohiense and identifies genome plasticity, including translocations and transposon activity, in clinical isolates.

This study identifies Rpd3 as essential for temperature-mediated morphogenesis and virulence in Histoplasma by regulating gene expression and histone acetylation.

This study identifies a genetic switch involving IS1245 transposition and Erp/MarP that controls colony morphology, virulence, and antibiotic resistance in Mycobacterium avium.

The paper shows that rapid gain and loss of chromosome seven in Histoplasma affects morphology, virulence, and environmental adaptation.

The paper identifies a large expansion of knottin genes in Histoplasma and shows their role in virulence and host cell lysis during macrophage infection.

This study creates a transcriptomic atlas of Coccidioides development, identifying spherule-enriched transcripts and RYP1-regulated genes critical for virulence.

This study optimizes in vitro spherulation in Coccidioides by adjusting culture conditions, media composition, and arthroconidium preparation to enhance spherule growth and endospore release.

The paper develops a method to infer strain composition in microbial mixed cultures using natural SNPs as barcodes, validated on Coccidioides posadasii isolates and applied to GWAS.

This paper develops a CRISPR/Cas9 system for efficient targeted gene disruption in Histoplasma, enabling high-efficiency mutagenesis and deletion of specific genes.