John Hoffer

This study identifies an estrogen receptor signaling program in HR+ breast cancer that suppresses immune responses by reducing T cell infiltration and HLA expression, suggesting therapeutic targets to enhance immunogenicity.

The paper identifies a subset of mismatch repair proficient colorectal cancers with high immune infiltration that may benefit from immune checkpoint inhibitors, using spatial profiling and genomics.

psudo is an interactive system that optimizes pseudocolor palettes for multichannel biomedical images to enhance perceptual distinction and reduce color confusion in overlapping channels.