Niu Huang

This paper describes a workflow for accurate de novo sequencing of antibody variable regions using mass spectrometry and open-source tools, achieving 100% accuracy in distinguishing leucine and isoleucine.

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

The paper presents cryo-EM structures of D1 dopamine receptor-Gs complexes in different nucleotide states, revealing conformational changes and a sequence motif that determines G protein selectivity.