Cell BiologybioRxivPreprint
Phosphatidylinositol 3-phosphate promotes 53BP1 condensate-like assembly at DNA double-strand breaks
Nan Xiong, Gaofeng Cui, Xuanqi Xu…·Michael S.Y. Huen
This study identifies PI(3)P binding to the 53BP1 tBRCT domain as essential for promoting 53BP1 condensate-like assembly at DNA double-strand breaks.
DOI 10.64898/2026.04.18.710733