James T. Sorrentino

This paper develops a combined systems antigenomics-serology workflow to characterize circulating IgG against Group A Streptococcus, revealing antigen repertoire and functional properties of antibodies in healthy and infected individuals.

The paper identifies a relationship between protein structure and glycan structure, introducing a glycoimpact matrix to predict glycosylation patterns and validate it through disease variants and engineered antibodies.

GlyCompareCT preprocesses glycomics data to address sparsity and non-independence, improving statistical power for downstream analysis.

This paper extends Linear Code to represent reaction rules in glycobiology, aiming to improve consistency and interoperability in glycan synthesis models.