Maria Gockert

The paper demonstrates the enzymatic synthesis of chemically modified RNA using a mutant T7 RNA polymerase and evaluates the impact of modifications on transcription efficiency and fidelity.

This study evaluates C14120-based LNPs for mRNA delivery, showing correlations between lipid composition and transfection efficiency in vitro and organ-specific targeting in vivo.

The paper identifies surface-bound RNA on extracellular vesicles and shows it is co-delivered to target cells, suggesting a new RNA uptake mechanism.

The paper identifies dual roles of ZC3H18 in promoting NEXT and antagonizing PAXT to co-activate RNA decay pathways for short substrates.