J. Robert Lane

This study investigates how membrane permeability affects the potency of fentanyl and isotonitazene, finding that fentanyl's extreme potency may be due to its ability to accumulate in membranes and repartition to bind receptors.

The paper investigates whether CCR8 is a high-affinity receptor for CCL18 and finds that CCR8 does not respond to CCL18 in multiple assays.

This study evaluates the in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor, finding that high intrinsic efficacy in Gi signaling correlates with increased risk of intoxication, regardless of signaling bias.