Pharmacology & ToxicologyCommunications BiologyPeer-reviewed
GRK specificity and beta gamma dependency determines a GPCR`s potential in biased agonism
Edda S. F. Matthees, Jenny C. Filor, Natasha Jaiswal…·Carsten Hoffmann
This paper shows that GRK2/3's interaction with Gβγ is essential for β-arrestin2 recruitment to GPCRs, linking G protein activation to biased agonism potential.
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