Author

Álvaro Urbano-Ispizúa

Hospital Clínic de BarcelonaORCID 0000-0002-7529-9399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Alba Rodríguez-GarcíaiD· 2 shared Aleix PratiD· 2 shared Berta MarzaliD· 2 shared Europa Azucena González‐NavarroiD· 2 shared Guillem Colell· 2 shared Guim Cascalló· 2 shared Irene Andreu-SaumelliD· 2 shared Joan CastellsaguéiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

Alba Rodríguez-GarcíaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 14, 2026

Context-dependent tonic signaling shapes the performance and manufacturability of a 4-1BB- based HER2 CAR-T cell therapy

Laura Angelats, Berta Marzal, Alba Rodríguez-García…·Sònia Guedan

This study shows that tonic signaling in 4-1BB-based HER2 CAR-T cells affects manufacturability and performance, with context-dependent outcomes based on manufacturing conditions.

DOI 10.64898/2026.05.11.724226

humanexperimental assay

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ImmunologybioRxivPreprintMay 2, 2026

In vivo CRISPR-based screen identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors

Paula Barbao, Alba Rodríguez-García, Ariel Galindo‐Albarrán…·Sònia Guedan

The paper identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors through an in vivo CRISPR screen and validates its role using single-cell RNA and ATAC-seq.

DOI 10.64898/2026.04.30.721530

mousescRNA-seq

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ImmunologyCell Reports MedicinePeer-reviewedOct 28, 2024

Integrative single-cell multi-omics of CD19CARpos and CARneg T cells suggest drivers of immunotherapy response in B-cell neoplasias

Mercedes Guerrero-Murillo, Aina Rill, Juan L. Trincado…·Pablo R. Menéndez

This study integrates single-cell multi-omics data from CAR-T cells to identify factors influencing immunotherapy response in B-cell neoplasias.

15 citations

humanscRNA-seq

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