Gheath Alatrash

This study identifies molecular features of MRD progression in MDS using single-cell multi-omic profiling, revealing dynamic evolutionary processes and immunoevasive mechanisms.

This study examines how chemotherapy affects clonal diversity and mutation patterns in hematopoietic stem cells, finding that melphalan increases mutational burden and promotes clonal aging, potentially leading to therapy-related myeloid neoplasms.

This study examines how allogeneic stem cell transplant affects subclonal evolution in chronic lymphocytic leukemia, identifying cellular homogeneity as a biomarker for immune response.

This study shows that IL-1B-mediated inflammation drives ineffective erythropoiesis in early-stage MDS and that canakinumab can reduce transfusion dependence in patients with DNMT3A and TET2 mutations.