Author

Dean A. A. Myles

Oak Ridge National LaboratoryORCID 0000-0002-7693-4964Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Gloria E. O. BorgstahliD· 2 shared Jahaun AzadmaneshiD· 2 shared Katelyn SlobodnikiD· 2 shared Kevin L. WeissiD· 2 shared Leighton CoatesiD· 2 shared Lucas R. StrubleiD· 2 shared Thomas KrölliD· 2 shared William E. LutziD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Gloria E. O. BorgstahlORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedFeb 22, 2025

The role of Tyr34 in proton-coupled electron transfer of human manganese superoxide dismutase

Jahaun Azadmanesh, Katelyn Slobodnik, Lucas R. Struble…·Gloria E. O. Borgstahl

This study investigates the role of Tyr34 in MnSOD catalysis using neutron diffraction, X-ray spectroscopy, and quantum chemistry calculations, revealing its impact on proton-coupled electron transfer.

14 citations

humanstructural biology

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BiochemistryNature CommunicationsPeer-reviewedJul 16, 2024

Revealing the atomic and electronic mechanism of human manganese superoxide dismutase product inhibition

Jahaun Azadmanesh, Katelyn Slobodnik, Lucas R. Struble…·Gloria E. O. Borgstahl

The paper investigates the mechanism of product inhibition in human MnSOD by combining neutron diffraction and X-ray absorption spectroscopy to determine the atomic and electronic structures of the enzyme in different states.

36 citations

humanexperimental assay

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