NeurosciencebioRxivPreprint
Short-chain di-carboxylates as positive allosteric modulators of the pH-dependent pentameric ligand-gated ion channel GLIC: requirement of an intact vestibular pocket
Catherine Van Renterghem, Ákos Nemecz, Sandrine Delarue‐Cochin…·Pierre‐Jean Corringer
The paper shows short-chain di-carboxylates modulate GLIC activity, with fumarate being the most potent, and reports a Cs+/Na+ permeability ratio for GLIC.
DOI 10.1101/2023.03.03.530963