Author

Josephine Mun Yee Ko

University of Hong KongORCID 0000-0002-7997-331XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Maria Li LungiD· 3 shared Anthony W.I. LoiD· 2 shared Bryan Chee-chad Lung· 2 shared Carissa Wing-Yan WongiD· 2 shared Dora Lai‐Wan KwongiD· 2 shared Valen Zhuoyou YuiD· 2 shared Wei DaiiD· 2 shared Yhi WongiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersCancer Biology

Maria Li LungORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 28, 2026

Disrupting Myeloid Persistence and Replenishment Enables Sustained Control of Esophageal Squamous Cell Carcinoma

Bryan Chee-chad Lung, Alvin Ka-Kiu Leung, Songran Liu…·Valen Zhuoyou Yu

The paper shows that combining CSF1R inhibition with low-dose decitabine suppresses both myeloid persistence and replenishment, leading to sustained control of ESCC in multiple models.

DOI 10.64898/2026.08.27.747541

humanmouse

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Genetic & Genomic MedicineJournal of Clinical InvestigationPeer-reviewedJan 1, 2025

Large-Scale Whole-Exome Sequencing Association Study Implicates Genetic Effects on Viral Oncogenesis and Tumor Microenvironment in Nasopharyngeal Carcinoma

Yanni Zeng, Chun-Ling Luo, Guo‐Wang Lin…·Jin‐Xin Bei

This study identifies three novel germline variants associated with nasopharyngeal carcinoma risk and introduces a refined polygenic risk score linked to EBV infection.

15 citationstop 1%

humanwhole-exome sequencing

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Cancer BiologyCancer LettersPeer-reviewedMay 31, 2024

ΔNp63-restricted viral mimicry response impedes cancer cell viability and remodels tumor microenvironment in esophageal squamous cell carcinoma

Valen Zhuoyou Yu, Shan Shan So, Bryan Chee-chad Lung…·Maria Li Lung

This study identifies ΔNp63's role in restricting viral mimicry response in ESCC, reducing cell viability, and modulating tumor microenvironment immune cells.

14 citations

humanbulk RNA-seq

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