Author

Eduardo Fonseca

Universidade da CoruñaORCID 0000-0002-8048-2681Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Adrián Varela-VázqueziD· 2 shared José Ramón CaeiroiD· 2 shared María D. MayániD· 2 shared Marta Varela-EiríniD· 2 shared Alexander Carneiro-Figueira· 1 shared Alfonso Blanco· 1 shared Alfonso Calañas Continente· 1 shared Amanda Guitián‐CaamañoiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Adrián Varela-VázquezORCID

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2 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedJul 4, 2025

Cx43 Enhances Response to BRAF/MEK Inhibitors by Reducing DNA Repair Capacity

Adrián Varela-Vázquez, Amanda Guitián‐Caamaño, Paula Carpintero-Fernández…·María D. Mayán

This study shows that Cx43 enhances the effectiveness of BRAF/MEKi by reducing DNA repair, leading to increased DNA damage and cellular senescence, and proposes a novel therapeutic approach using sEVs.

11 citations

humanexperimental assay

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Cell BiologybioRxivPreprintJun 28, 2019

Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritis

Marta Varela-Eirín, Adrián Varela-Vázquez, Carlos Luis Paíno…·María D. Mayán

This study shows that olive-derived polyphenols like oleuropein target Cx43 and senescence in osteoarthritis cells, promoting cartilage regeneration and reducing inflammation.

DOI 10.1101/686535

humanproteomics

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