NeurosciencebioRxivPreprint
eIF2Bϵ phosphorylation activates integrated stress response-mediated protein translation and links stress signalling toamyloidogenesis in Alzheimer's disease
Hugo Fanlo-Ucar, Clara Planas-Clopes, Oriol Bagudanch…·Francisco J. Muñoz
This study identifies a novel GSK-3β-eIF2Bε-BACE1 axis that links stress response dysregulation to amyloidogenesis in Alzheimer's disease, independent of canonical eIF2 phosphorylation.
DOI 10.1101/2025.11.03.686297