Julia Yue Cui

PCB-Exposed Gut Microbiota Recapitulate Neurobehavioral Deficits and Reprogram Hippocampal Transcriptomic Signatures

This study shows that transferring PCB-exposed gut microbiota to offspring reproduces neurobehavioral deficits and induces sex-biased molecular changes in the brain.

Triple-Omics Analysis Unveiled the Neuroprotective Mechanisms of Akkermansia muciniphila in an Environmental Exposure-Linked Mouse Model of Alzheimer's Disease

This study identifies A. muciniphila's neuroprotective effects against Cd-induced hippocampal dysfunction through restoration of post-transcriptional RNA regulation and splicing patterns.

The microbial soy metabolite S-equol mitigates cadmium neurotoxicity in mice

This study shows that S-equol, a microbial metabolite, reduces cadmium-induced neurotoxicity in mice by restoring neural gene expression and is associated with lower levels in humans carrying the apolipoprotein E4 allele.

Akkermansia muciniphila prevents cadmium-induced cognitive impairment through gut microbiome mediated mechanisms

This study shows that Akkermansia muciniphila prevents cadmium-induced cognitive impairment in mice through gut microbiome and metabolite mechanisms, not by reducing brain cadmium levels.

In vivo exposure of mixed microplastic particles in mice and its impacts on the murine gut microbiome and metabolome

This study shows that microplastic exposure alters gut microbiome composition and serum metabolome in mice, with sex-specific and dose-dependent effects.

Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylases

The paper shows that butyrate rescues CPF-induced social deficits in zebrafish by inhibiting class I HDACs, linking CPF exposure to gut microbiome, metabolome, and epigenetic changes.

Cadmium-induced gut dysbiosis precedes the onset of hippocampus-dependent learning and memory deficits in mice

This study shows Cd exposure causes gut dysbiosis before cognitive deficits in mice, with altered gut microbiota linked to hippocampus-dependent memory impairments.

Single-cell transcriptomics showed that maternal PCB exposure dysregulated ER stress-mediated cell type-specific responses in the liver of female offspring

This study uses single-cell RNA sequencing to show that maternal PCB exposure alters cell type-specific gene expression and pathways in the liver of female offspring, affecting metabolic and immune functions.

Oral Exposure to Benzalkonium Chlorides in Male and Female Mice Reveals Sex-Dependent Alteration of the Gut Microbiome and Bile Acid Profile

This study shows oral BAC exposure reduces gut microbiome diversity and secondary bile acids in female mice more than males.

Genome-scale metabolic model predicts mechanistic differences in metabolic gradient of spatially resolved small intestine villi

The paper uses spatial transcriptomics data to reconstruct location-specific genome-scale metabolic models in the small intestine, revealing metabolic differences between villus top and bottom enterocytes.