Sebastian G. Wicha

The paper introduces a high-throughput in vitro assay for evaluating antimalarial drug combinations and their pharmacodynamic interactions, showing improved efficiency and resolution compared to existing methods.

This paper shows that high MYCN levels in neuroblastoma reduce L1CAM expression, limiting CAR T cell efficacy, and that inhibiting MYCN with MLN8237 restores L1CAM and enhances CAR T cell activity.