Aguirre A. de Cubas

This study shows that high-affinity CAR signaling in human Tregs leads to increased cytotoxicity and inflammatory cytokine production, while lower affinity reduces these effects.

This paper evaluates SpiD3, a novel spirocyclic dimer, showing potent anti-leukemic effects in CLL cells, including resistance to ibrutinib, by targeting NF-κB signaling and the UPR.