Single-cell transcriptional changes of artemisinin-sensitive K13C580 and artemisinin-resistant K13580Y Plasmodium falciparum upon dihydroartemisinin exposure
Sean V. Connelly, Clark Cunningham, Ian Petrow…·Cliff I. Oduor
This study uses single-cell RNA sequencing to compare transcriptional changes in artemisinin-sensitive and resistant Plasmodium falciparum strains after dihydroartemisinin exposure, identifying metabolic and protein export differences and a potential therapeutic target.