Wouter P. F. Driever

This study develops clickable fatty acids to quantify single-cell uptake by immune cells, finding polyunsaturated fatty acids are preferentially taken up by various immune cell types.

The paper identifies foamy microglia as contributors to disease progression in secondary progressive MS, linking oxylipins to lesion expansion and proposing monoacylglycerol lipase as a therapeutic target.

The paper shows that disrupting tonic endocannabinoid signaling increases HPA axis activation by enhancing CRH neuron activity in the PVN, leading to stress-like behaviors and elevated corticosterone.