BiochemistrybioRxivPreprint
Towards the Development of Isoenergetic Peptide Nucleic Acid Based Probes Targeting Double-Stranded RNAs Through Enhancing Sequence-Specific Stacking Interactions
Rongguang Lu, Kun Xi, Ruiyu Lin…·Gang Chen
This paper investigates how modifying PNA with s2U adjacent to Q residues enhances binding affinity and functional activity toward dsRNAs, demonstrating broader applicability in targeting structured RNA structures.
DOI 10.1101/2025.06.28.662161