Author
Broad InstituteORCID 0000-0002-9948-2761Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Sean A. Misek, Anna Borgenvik, Daniel Christen…·Pratiti Bandopadhayay
The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.
Alissandra L. Hillis, Timothy D. Martin, Haley E. Manchester…·Alex Toker
This study identifies a synergistic effect between AKT inhibitors and pitavastatin in killing triple-negative breast cancer cells by targeting cholesterol trafficking.
Xiaoping Yang, Andrew Lee Hong, Ted Sharpe…·David E. Root
The paper introduces a method to screen large variant libraries with mutations across wide regions using improved mutant detection software, enabling accurate variant calling and counting from sequencing data.
Joana Damas, Graham M. Hughes, Kathleen C. Keough…·Harris A. Lewin
The paper predicts the broad host range of SARS-CoV-2 by analyzing ACE2 conservation across vertebrates and identifying high-risk species.
Peter C. DeWeirdt, Annabel K. Sangree, Ruth E. Hanna…·John G. Doench
The paper presents a method to generate isogenic cell pairs and screen them with CRISPR-Cas9 libraries to identify genetic interactions, demonstrating applications for BCL2L1, MCL1, and PARP1.