BioengineeringbioRxivPreprint
Rationally designed modular STAT-activating scaffolds enforce cell-intrinsic transcriptional programs augmenting the anti-tumor potency of CAR T cells
Christopher P Saxby, Taylor K Ishida, James M. Rosser…·Michael C. Jensen
This study designs and tests STAT-activating scaffolds to enhance CAR T cell anti-tumor potency, finding that LASI-3 improves function without lymphoproliferative side effects.
DOI 10.1101/2023.12.22.573170