Beatrice S. Melin

This study develops a novel polygenic risk score (PRS-CS) for glioma that outperforms existing methods, improving risk prediction and subtype classification using genome-wide association study data.

The paper reports a whole-genome sequenced control population from northern Sweden, revealing genetic substructure and improving variant imputation accuracy.

This study assesses polygenicity and risk prediction using common variants across 14 cancers, finding varying numbers of susceptibility variants and risk score effectiveness.