Thomas Böttcher

The paper identifies Esp and Csp as functional glutamyl endopeptidases from commensal staphylococci that activate itch signaling and disrupt skin barrier function in atopic dermatitis.

This paper demonstrates positive cooperativity between subunits in the M. tuberculosis 20S proteasome core particle by using a hybrid subunit assembly and isotopic-coding strategy to resolve symmetry-masked allostery.

This paper activates the ilicicolin biosynthetic pathway in Trichoderma reesei to discover a novel antifungal compound, ilicicolin K, with similar antifungal activity to ilicicolin H.

This study shows that the Parkinson's drug entacapone disrupts gut microbiome homeostasis by sequestering iron, affecting microbial metabolism and promoting iron-scavenging organisms with resistance genes.