Author

Georgios Efthymiou

Centre National de la Recherche ScientifiqueORCID 0000-0003-0243-1456Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Fabienne GuillaumondiD· 2 shared François BertucciiD· 2 shared Pascal FinettiiD· 2 shared Richard TomasiniiD· 2 shared Sophie VasseuriD· 2 shared Christophe LachaudiD· 1 shared Cindy Neuzillet· 1 shared Coralie Compare· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Fabienne GuillaumondORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The methionine cycle sustains the mesenchymal phenotype of tumor cells and drives PDA progression

Sophie Vasseur, Fabienne Guillaumond, Metay Elodie, Quentin Da-Costa, Pascal Finetti, François Bertucci, Richard Tomasini, Nelson J. Dusetti, Émilie Mamessier, Georgios Efthymiou, Emilie Jaune-Pons, Victoire Gouirand, Sarah Simba Tubiana, Cindy Neuzillet, Eugenie Lohmann, , Pierre Grenot

This study identifies the methionine cycle as a driver of mesenchymal traits in PDA, showing that targeting SAHH reduces metastasis and improves survival.

bioRxiv · Nov 7, 2026 · PreprintCancer Biology

The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage.

Georgios Efthymiou, Coralie Compare, Eugénie Lohmann, Paraskevi Kousteridou, Pierre Marie Bertrand, Heather S. Carr, Issam Ben‐Sahra, Ivan Nemazanyy, Sarah-Simha Tubiana, Zainab Hussain, Pascal Finetti, François Bertucci, Ghislain Bidaut, Christophe Lachaud, Fabienne Guillaumond, , Sophie Vasseur

This study shows that the extracellular matrix promotes guanylate production in pancreatic cancer cells, reducing oxaliplatin-induced DNA damage and enhancing proliferation.

Science Advances · Dec 12, 2025Peer-reviewedCancer Biology