Émilie Mamessier

The methionine cycle sustains the mesenchymal phenotype of tumor cells and drives PDA progression

This study identifies the methionine cycle as a driver of mesenchymal traits in PDA, showing that targeting SAHH reduces metastasis and improves survival.

Circulating colorectal tumor cells remodel their surfaceome to increase their viability and metastatic potential in the bloodstream

The paper identifies PTK7 as a marker for colorectal cancer cell plasticity and metastatic potential, showing its loss in circulating tumor cells enables stress resistance and metastasis through surfaceome remodeling.

Multiomic dissection of HR+/HER2- invasive lobular breast carcinoma reveals mobilized yet dysfunctional anti-tumor immunity shaped by tumor-stroma crosstalk and impaired antigen presentation

This study analyzes the immune landscape of HR+/HER2- invasive lobular breast carcinomas using multi-omics approaches, revealing mobilized yet dysfunctional anti-tumor immunity due to impaired antigen presentation and immunosuppressive stroma.

TTLL6-mediated Polyglutamylation of PurA Maintains Colonic Crypt Integrity

This study identifies TTLL6 as a key polyglutamylase in the colon, showing its role in maintaining crypt integrity and preventing colon cancer progression.

Multi-omic analysis of colorectal adenocarcinoma identifies a new subtype of myofibroblastic cancer-associated fibroblast expressing high level of B7-H3 and with poor prognosis value.

This study identifies a new subtype of myofibroblastic cancer-associated fibroblasts expressing high B7-H3 in colorectal cancer, which is associated with poor prognosis.