François Bertucci

The methionine cycle sustains the mesenchymal phenotype of tumor cells and drives PDA progression

This study identifies the methionine cycle as a driver of mesenchymal traits in PDA, showing that targeting SAHH reduces metastasis and improves survival.

The atypical cadherin CELSR2 regulates distinct epithelial-mesenchymal states and oxidative phosphorylation in triple-negative breast cancer

This study identifies CELSR2 as a regulator of epithelial-mesenchymal plasticity and oxidative phosphorylation in triple-negative breast cancer, showing its role in shaping tumor heterogeneity.

Multiscale Modeling Uncovers Macrophage Infiltration and TNF-α Signaling Networks for Targeting in Inflammatory Breast Cancer Tumor Emboli

This study identifies macrophage infiltration and TNF-α signaling networks in IBC tumor emboli and shows that targeting these pathways with Birinapant inhibits tumor emboli in vivo.

Circulating colorectal tumor cells remodel their surfaceome to increase their viability and metastatic potential in the bloodstream

The paper identifies PTK7 as a marker for colorectal cancer cell plasticity and metastatic potential, showing its loss in circulating tumor cells enables stress resistance and metastasis through surfaceome remodeling.

TERT drives liver tumorigenesis beyond telomere elongation

This study shows TERT promotes liver tumors independently of telomere elongation, revealing molecular and metabolic features relevant to immunotherapy response.

Multiomic dissection of HR+/HER2- invasive lobular breast carcinoma reveals mobilized yet dysfunctional anti-tumor immunity shaped by tumor-stroma crosstalk and impaired antigen presentation

This study analyzes the immune landscape of HR+/HER2- invasive lobular breast carcinomas using multi-omics approaches, revealing mobilized yet dysfunctional anti-tumor immunity due to impaired antigen presentation and immunosuppressive stroma.

TTLL6-mediated Polyglutamylation of PurA Maintains Colonic Crypt Integrity

This study identifies TTLL6 as a key polyglutamylase in the colon, showing its role in maintaining crypt integrity and preventing colon cancer progression.

The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage.

This study shows that the extracellular matrix promotes guanylate production in pancreatic cancer cells, reducing oxaliplatin-induced DNA damage and enhancing proliferation.

Multi-omic analysis of colorectal adenocarcinoma identifies a new subtype of myofibroblastic cancer-associated fibroblast expressing high level of B7-H3 and with poor prognosis value.

This study identifies a new subtype of myofibroblastic cancer-associated fibroblasts expressing high B7-H3 in colorectal cancer, which is associated with poor prognosis.