Quentin Da Costa

The methionine cycle sustains the mesenchymal phenotype of tumor cells and drives PDA progression

This study identifies the methionine cycle as a driver of mesenchymal traits in PDA, showing that targeting SAHH reduces metastasis and improves survival.

Circulating colorectal tumor cells remodel their surfaceome to increase their viability and metastatic potential in the bloodstream

The paper identifies PTK7 as a marker for colorectal cancer cell plasticity and metastatic potential, showing its loss in circulating tumor cells enables stress resistance and metastasis through surfaceome remodeling.

TERT drives liver tumorigenesis beyond telomere elongation

This study shows TERT promotes liver tumors independently of telomere elongation, revealing molecular and metabolic features relevant to immunotherapy response.