Author

Eva Konkoľová

Czech Academy of SciencesORCID 0000-0003-0285-3843Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

Evžen BouřaiD· 2 shared Martin KlímaiD· 2 shared AkshatKumar NigamiD· 1 shared Alán Aspuru‐GuzikiD· 1 shared Anshul Bharat KundajeiD· 1 shared Christoph GorgullaiD· 1 shared Dominika ChalupskáiD· 1 shared Fengling LiiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Evžen BouřaORCID

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2 papers

Recent·Most cited

Molecular BiologyStructurePeer-reviewedMay 22, 2024

Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase

Kateřina Krejčová, Petra Krafčíková, Martin Klíma…·Evžen Bouřa

The paper structures and biochemically analyzes the MTase and RdRp domains of Ntaya virus NS5, showing conserved enzymatic centers across Flaviviridae but differing MTase activities.

16 citationstop 3%

protein structureexperimental assay

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BiochemistryDigital DiscoveryPeer-reviewedJan 1, 2024

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

AkshatKumar Nigam, Matthew F. D. Hurley, Fengling Li…·Alán Aspuru‐Guzik

This paper introduces a computational pipeline for identifying SARS-CoV-2 nsp14 inhibitors using virtual screening, identifying seven candidates including NSC620333 and SS148, with experimental validation of binding affinity and structural insights.

14 citations

virusproteomics

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