Marcel Fabian Pohly

The paper uses drug perturbations and RNA sequencing to map pathway connectivity in CLL, showing how genetic aberrations modulate drug responses and pathway interactions.

DemoTape is a computational method for demultiplexing targeted single-cell DNA sequencing data, showing improved performance over existing methods for RNA sequencing data.

This study uses in vivo single-cell CRISPR to identify distinct TNF-α programs in clonal expansion and tumorigenesis, showing their roles in epithelial transformation and tumor initiation.