Jatinder Kaur Lamba

This paper identifies IKKβ and NR4A1 as drivers of AML and develops a PROTAC to degrade them, showing potent cytotoxicity and reduced leukemia progression in mice.

BEAM integrates multiple omics profiles with multiple clinical outcomes using bootstrap resampling to identify significant associations, outperforming existing methods in simulations and a pediatric leukemia application.

This study identifies HNRNPC as a critical therapeutic target in AML by showing its role in regulating Myc-Max activity through alternative splicing.