Author

Jacky H. K. Chen

University of PittsburghORCID 0000-0003-0809-8340Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Da Zhuan XuiD· 1 shared Harrison H. TruscottiD· 1 shared Jeffrey J. GrayiD· 1 shared Kendall A. ReidiD· 1 shared Lee‐Shin ChuiD· 1 shared Sudeep SarmaiD· 1 shared

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1 shared paperBiophysics

Da Zhuan XuORCID

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1 paper

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BiophysicsbioRxivPreprintNov 28, 2025

Can We Extract Physics-like Energies from Generative Protein Diffusion Models?

Sudeep Sarma, Harrison H. Truscott, Da Zhuan Xu…·Jeffrey J. Gray

This paper examines whether diffusion models can extract physics-like energies for protein docking, finding they can recover energy funnels comparable to Rosetta in 9 out of 25 cases.

4 citations

protein structuredeep learning

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