Tanner Michael Johanns

This study compares two murine glioblastoma models using single-cell and spatial transcriptomics to reveal distinct tumor-immune dynamics and their correlation with human GBM survival.

The paper maps CD4+ T cell landscapes in glioblastoma, revealing effector and bystander populations with distinct clonal and transcriptional features across tumor and blood compartments.

The paper analyzes TILs in GBM using CITE-seq and scRNA-seq to show that CD8+ T cells are predominantly clonally expanded GZMK+ effector cells, lacking canonical exhaustion.

The paper predicts MHC anchor positions for 328 HLA alleles and shows that incorporating these improves neoantigen identification by correcting misclassified candidates in tumor samples.