Emiliano Maiani

This study investigates phospho-regulation and flanking regions in autophagy-related SLiMs using optineurin-LC3B as a case, revealing structural mechanisms and disease mutation impacts.

MutateX automates in-silico saturation mutagenesis to predict free energy changes of protein mutations, supporting analysis of disease-associated mutations and protein design.

The paper evaluates 43 methods for predicting intrinsically disordered regions and binding regions in proteins, finding that deep learning methods outperform older physicochemical approaches but binding prediction remains challenging.