This study establishes CLSI-endorsed epidemiological cutoff values (ECVs) for antifungal susceptibility in clinically relevant Sporothrix species using broth microdilution data from 19 laboratories.

DOI 10.64898/2025.12.19.695392

experimental assaydrug response / drug discovery

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MicrobiologyFEMS Yeast ResearchPeer-reviewedJan 1, 2025

The experimentally evolved fluconazole-resistant Clade II isolates of Candidozyma auris exhibit a distinct lipid compositional landscape, highlighting intra-clade sphingolipid heterogeneity

Praveen Kumar, Basharat Ali, Mohit Kumar…·Rajendra Prasad

This study compares sphingolipid profiles of fluconazole-resistant Candidozyma auris isolates to identify intra-clade lipid compositional differences linked to antifungal resistance.

DOI 10.1093/femsyr/foaf030

C. elegansstatistical model

𝕏 PostBluesky

MicrobiologybioRxivPreprintSep 20, 2023

Microevolution of clade II isolates of Candida auris highlights multifaceted intra-clade heterogeneity in acquiring resistance towards amphotericin B

Anshu Chauhan, Praveen Kumar, Mohit Kumar…·Rajendra Prasad

This study evolves two clade II Candida auris isolates to develop amphotericin B resistance, revealing distinct mechanisms and intra-clade heterogeneity in resistance acquisition.

DOI 10.1101/2023.09.20.558730

C. eleganswhole-genome sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintJan 29, 2021

Functional and comparative genome analysis reveals clade-specific genome innovations in the killer fungus Candida auris

Aswathy Narayanan, Rakesh Netha Vadnala, Promit Ganguly…·Kaustuv Sanyal

The paper identifies centromere structures and evolutionary changes in Candida auris and related species, revealing clade-specific karyotype innovations.

1 citation

humanwhole-genome sequencing

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