Richard Sean Lee

This paper shows that the H3E50K mutation in histone H3 promotes oncogenic activity by enhancing cell migration, invasion, and epithelial-mesenchymal transition.

The paper uses a budding yeast model to study the functional effects of oncogenic histone missense mutations and identifies suppressor genes involved in histone function and transcriptional regulation.

The paper creates a yeast model of SHRF mutations in EXOSC2 and compares it to an EXOSC3 mutation model, showing distinct RNA exosome functional impacts.