Nathali Kaushansky

This study profiles circulating hematopoietic stem and progenitor cells in MPN patients, identifying transcriptional signatures and quantitative readouts to distinguish MF from other MPNs and predict progression.

This study identifies and characterizes circulating endothelial cells (CECs) using single-cell data, revealing their diverse origins and plasticity, and links them to angiogenic programs in cancer.

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

The paper characterizes age-related and inter-individual variation in circulating hematopoietic stem cells and establishes a normal reference to identify hematological disorders.

The paper examines DNA methylation stability after MMEJ and NHEJ repair mechanisms, finding that methylation levels remain stable despite repair-induced deletions and in the presence of a DNMT3A mutation.

The paper investigates how center-surround antagonism in retinal starburst amacrine cells contributes to direction selectivity in ganglion cells.

The paper identifies microhomology-mediated end joining (MMEJ) as the mechanism behind recurrent deletions in myeloid malignancies and shows that these deletions occur in multipotent hematopoietic stem cells.