NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
The process of Lewy body formation, rather than simply alpha-synuclein fibrillization, is the major driver of neurodegeneration in synucleinopathies
Anne‐Laure Mahul‐Mellier, Johannes Burtscher, Niran Maharjan…·Hilal Ahmed Lashuel
This study develops a neuronal model of Lewy body formation and shows that the process of Lewy body maturation, not just fibrillization, drives neurodegeneration in synucleinopathies.
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