Kathleen M. Darcy

ShapeUpLMD automates ROI optimization for laser microdissection, improving tumor purity and spatial accuracy in multi-omic tissue profiling.

The paper identifies conserved protein alterations and elevated MUC16 in low-grade serous ovarian cancers through quantitative proteomics and validation across multiple datasets.

ProteoMixture estimates cell type proportions in bulk tissue proteomics data using optimized protein signatures validated on high-grade serous ovarian cancer samples.

This study examines the relationship between genetic ancestry, somatic mutation frequency, and histologic subtypes in high-grade endometrial cancer, finding associations between local ancestry and tumor mutation burden and histologic subtypes.

This study identifies HN1 as a predictive and pharmacodynamic biomarker of metformin response in endometrioid endometrial cancer, showing it is elevated in responders and decreases after treatment.